Rational Drug Design (Record no. 16197)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02012nam a2200217Ia 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 140223b1999 xxu||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9780387987538 |
| Terms of availability | 0.00 |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 615.19 |
| Item number | RAT |
| 245 ## - TITLE STATEMENT | |
| Title | Rational Drug Design |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc | New York |
| Name of publisher, distributor, etc | Springer-Verlag |
| Date of publication, distribution, etc | 1999 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 206p |
| 500 ## - GENERAL NOTE | |
| General note | Drug research and discovery are of critical importance in human health care. Computational approaches for drug lead discovery and optimization have proven successful in many recent research programs. These methods have grown in their effectiveness not only because of improved understanding of the basic science - the biological events and molecular interactions that define a target for therapeutic intervention - but also because of advances in algorithms, representations, and mathematical procedures for studying such processes. This volume surveys some of those advances. A broad landscape of high-profile topics in computer-assisted molecular design (CAMD) directed to drug design are included. Subject areas represented in the volume include receptor-based applications such as binding energy approximations, molecular docking, and de novo design; non-receptor-based applications such as molecular similarity; molecular dynamics simulations; solvation and partitioning of a solute between aqueous and nonpolar media; graph theory; non-linear multidimensional optimization, processing of information obtained from simulation studies, global optimization and search strategies, and performance enhancement through parallel computing. |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| Personal name | Drug Design |
| 9 (RLIN) | 105135 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Truhlar, Donald G. |
| Relator term | Editor |
| 9 (RLIN) | 105136 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Blaney, Jeff |
| Relator term | Editor |
| 9 (RLIN) | 105137 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Hopfinger, Anthony J. |
| Relator term | Editor |
| 9 (RLIN) | 105138 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Howe, W. Jeffrey |
| Relator term | Editor |
| 9 (RLIN) | 105139 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dammkoehler, Richard A. |
| Relator term | Editor |
| 9 (RLIN) | 105140 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | Dewey Decimal Classification |
| Item type | Book |
| 995 ## - RECOMMENDATION 995 [LOCAL, UNIMARC FRANCE] | |
| Origin of item (home branch) (free text) | Pharmacy Reference |
| Genre | P0002468 |
| Section | 615.19 |
| Recipient parent organisation code | P0002468 |
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