Henry's Clinical Diagnosis and Management by Laboratory Methods

Required reading in clinical pathology since 1908! Comprehensive coverage gives you an in-depth understanding of lab test selection and interpretation of results. A new full-color layout makes reference much easier. What's more, new chapters on laboratory regulations, nutrition, point-of-care testing, bioterrorism, proteomics, microarray analysis, and the human genome project – as well as a completely new section on cancer testing and meticulous updates from cover to cover – put all the latest, most essential knowledge at your fingertips. Key Features * Describes the scientific foundation, and clinical application of today's complete range of laboratory tests. * Presents a new full-color layout, many new color illustrations and visual aids, and a new organ-system organization to make reference easier and faster. * Provides new chapters on Proteomics, Microarray Analysis, and Human Genome Project in Laboratory-Based Diagnostics – authored by pioneering experts who helped originate these techniques. * Delivers a new chapter on Laboratory Regulations that details stringent new guidelines in the U.S. and abroad (such as CLIA88 and HIPAA), inspection, accreditation, and proficiency testing. * Includes a completely new section on Cancer Testing that covers all aspects of molecular cancer testing, oncoproteins and early tumor detection, and tumor markers. * Incorporates sweeping updates on instrumentation and clinical laboratory automation * medicolegal aspects of environmental toxicology, occupational exposures, and workplace/employment drug testing * molecular microbiology testing * bioterrorism * nutritional status testing * point-of-care testing * and many other evolving topics. * Offers an increased emphasis on error detection, correction, and prevention as well as cost-effective test selection. About the Author Richard A. McPherson MD, Professor and Chairman, Division of Clinical Pathology, Virginia Commonwealth University, Richmond, Virginia Matthew R. Pincus, MD, PhD, Professor, Department of Pathology, State University of New York Health Sciences Center at Brooklyn; Chairman, Department of Pathology and Laboratory Medicine, New York Harbor Veterans Affairs Health Care System, Brooklyn, NY Table of Contents PART I: The Clinical Laboratory o 1. The Clinical Laboratory: Organization, Purpose and Practice o 2. Laboratory Regulations o 3. Principles of Instrumentation o 4. Clinical Laboratory Automation o 5. Interpreting Laboratory Results o 6. Informatics, Imaging and Interoperability o 7. Laboratory Statistics o 8. Clinical Laboratory Quality Assurance PART II: Clinical Chemistry o 9. Evaluation of Renal Function, Water, Electrolytes, Acid-Base Balance and Blood Gases o 10. Metabolic Intermediates, Inorganic Ions and Biochemical Markers of Bone Metabolism o 11. Carbohydrates o 12. Lipids and Dyslipoproteinemia o 13. Specific Proteins o 14. Evaluation of Liver Function and Injury o 15. Protein Markers of Disease o 16. Evaluation of Endocrine Function o 17. Toxicology and Therapeutic Drug Monitoring o 18. Nutrition PART III: Urine and Other Body Fluids o 19. Basic Examination of Urine o 20. Cerebrospinal, Synovial, and Serious Body Fluids o 21. Andrology Laboratory and Fertility Assessment o 22. Laboratory Management of Assisted Reproductive Technology o 23. Laboratory Aspects of Gestation Management o 24. Laboratory Diagnosis of Gastrointestinal Tract and Pancreatic Disorders PART IV: Hematology, Coagulation and Transfusion Medicine o 25. Basic Examination of Blood o 26. Hematopoiesis o 27. Erythrocytic Disorders o 28. Leukocytic Disorders o 29. Blood Platelets o 30. Coagulation, Fibrinolysis and Hypercoagulation o 31. Immunohematology o 32. Transfusion Medicine o 33. Hemapheresis o 34. Tissue Banking and Progenitor Cell o 35. Point-of-Care Testing (POCT) PART V: Immunology and Immunopathy o 36. Overview of the Immune System and Immunologic Disorders o 37. Immunoassays and Immunochemistry o 38. Laboratory Evaluation of the Cellular Immune System o 39. Laboratory Evaluation of Immunoglobin Function and Humoral Immunity o 40. Complement and Kinins: Mediators of Inflammation o 41. Cytokines and Adhesion Molecules o 42. HLA: The Major Histocompatibility Complex of Man o 43. The Major Histocompatibility Complex and Disease o 44. Immunodeficiency Disorders o 45. Clinical and Laboratory Evaluation of Systemic Rheumatic Diseases o 46. Vasculitis o 47. Organ-Specific Autoimmune Diseases o 48. Allergic Diseases PART VI: Medical Microbiology o 49. Viral Infections o 50. Chlamydial, Rickettsial, and Mycoplasmal Infections o 51. Medical Microbiology o 52. In Vitro Testing of Antimicrobial Agents o 53. Spirochete Infections o 54. Mycobacteria o 55. Mycotic Diseases o 56. Medical Parasitology o 57. Molecular Pathology of Infectious Diseases o 58. Specimen Collection and Handling for Diagnosis of Infectious Diseases o 59. Bioterrorism PART VII: Molecular Pathology o 60. An Introduction to Molecular Pathology o 61. Molecular Diagnostics: Basic Principles and Techniques o 62. Polymerase Chain Reaction (PCR) and Other Amplification Technology o 63. Hybridization Array Technology o 64. Applications for Cytogenetics in Modern Pathology o 65. Establishing a Molecular Diagnostics Laboratory o 66. Molecular Techniques in the Hematopoietic Neoplasms o 67. Molecular Diagnosis of Genetic Diseases o 68. Forensic Identity Testing by DNA Analysis o 69. Proteomics o 70. Microarray Analysis o 71. Human Genome Project in Laboratory-Based Diagnostics PART VIII: Cancer Testing o 72. Molecular Testing o 73. Oncoproteins and Early Tumor Detection o 74. Diagnosis and Management of Cancer Using Serologic Tumor Markers o 75. Use of DNA Polymorphism and Other Genetic Markers