Fundamental Immunology

CONTENTS SECTION I: INTRODUCTION The Immune System SECTION II: ORGANIZATION AND EVOLUTION OF THE IMMUNE SYSTEM Lymphoid Tissues & Organs Evolution of the Immune System SECTION III: IMMUNOGLOBULINS AND B LYMPHOCYTES Immunoglobulins: Structure & Function Antigen Antibody Interactions and Monoclonal Antibodies Immunoglobulins: Molecular Genetics Lymphocyte Development B Lymphocyte Signaling Mechanisms and Activation B Lymphocyte Biology SECTION IV: T LYMPHOCYTES T Cell Antigen Receptors T Lymphocyte Signaling Mechanisms and Activation Development of T Cells Peripheral T Lymphocyte Responses and Function SECTION V: THE INTERSECTION OF INNATE AND ADAPTIVE IMMUNITY Innate Immunity Dendritic Cells Natural Killer Cells NK T Cells and Other Innate-Like T and B Lineages Macrophages and Phagocytosis Major Histocompatibility Complex (MHC) Molecules: Structure, Function, and Genetics Cell Biology of Processing and Presentation SECTION VI: REGULATION AND EFFECTOR FUNCTIONS OF THE IMMUNE RESPONSE Immunogenicity and Antigen Structure Fc Receptors and Their Role in Immune Regulation and Inflammation Type I Cytokines and Interferons and Their Receptors Interleukin-1 Family of Ligands and Receptors TNF-related Cytokines in Immunity, Chemokines Programmed Cell Death Immunologic Memory Immunological Tolerance Regulatory/Suppressor T Cells The Mucosal Immune System Neural Immune Interactions Marketon and Esther Sternberg Complement Cytotoxic T Lymphocytes SECTION VII: IMMUNITY TO INFECTIOUS AGENTS The Immune Response to Parasites Immunity to Viruses Immune Responses to Intracellular Bacteria Immunity to Extracellular Bacteria, Immunology of HIV Infection SECTION VIII: IMMUNOLOGIC MECHANISMS IN DISEASE Systemic Autoimmunity Organ-Specific Autoimmunity Immunological Mechanisms of Allergic Disorders Transplantation Immunology Tumor Immunology Primary Immunodeficiency Diseases INDEX