Nitric Oxide: Biology and Pathobiology

Section I. Chemical Biology Chapter1. Determinants of Nitric Oxide Chemistry: Impact of Cell Signaling Processes Chapter 2. Nitric oxide redox biochemistry in lipid environments Chapter 3. Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration Chapter 4. Systems Approaches to Unraveling Nitric Oxide Response Networks in Prokaryotes Section II. Principles of Biology A. Nitric Oxide Synthases Chapter 5. Uncoupling of endothelial NO synthase (eNOS) in cardiovascular disease and its pharmacological reversal Chapter 6. Tetrahydrobiopterin: An essential cofactor for Nitric Oxide Synthases and Amino Acid Hydroxylases Chapter 7. Regulation of the expression of inducible nitric oxide synthase Chapter 8. Molecular Regulation of Inducible Nitric Oxide Synthase B. Guanylate Cyclase and Cyclic GMP Chapter 9. Soluble Guanylate Cyclase: Allosteric Activation and Redox Regulation C. Nitric Oxide Signaling Chapter 10. Untargeted Discovery of NO-modified Proteins Chapter 11. Fatty Acid Transduction of Nitric Oxide Signaling: Cyclooxygenases, Lipoxygenases and Nitro-Fatty Acids Chapter 12. Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1 Chapter 13. The Regulation of Cell Energetics and Mitochondrial Signaling by Nitric Oxide D. Regulation of Nitric Oxide Production Chapter 14. Nitric oxide-asymmetric dimethylarginine system in endothelial cell senescence E. Nitric Oxide and Remodeling Chapter 15. The Role of Nitric Oxide in Apoptosis and Autophagy: Biochemical and Computational Studies F. Nitrite and Nitrate Chapter 16. NO formation from inorganic nitrate and nitrite Chapter 17. Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential Chapter 18. Nitrite Therapy for Ischemic Syndromes Chapter 19. Nitrite and heme globins: Reaction mechanisms and physiological targets Section III. Principles of Pathobiology A. Nitric Oxide and Cardiovascular Function Chapter 20. Nitric Oxide in Vascular Damage and Regeneration Chapter 21. Free radicals as atherosclerotic risk-The relation of NO- Chapter 22. The role of oxidative stress in endothelial dysfunction and vascular inflammation B. Pathophysiological Mechanisms of Nitric Oxide Chapter 23. Nitric oxide, oxidative stress, immune response and critical care Chapter 24. Reactive Metabolites of Oxygen and Nitrogen in Liver Ischemia and Reperfusion Injury Chapter 25. Nitric oxide in airway inflammation Chapter 26.Novel therapeutic applications of nitric oxide (NO) in the inhibition of tumor malignancy and reversal of resistance