Manual of Industrial Microbiology and Biotechnology

New Approaches to Microbial Isolation Selective Isolation of Actinobacteria SECTION I ISOLATION AND SCREENING FOR SECONDARY METABOLITES AND ENZYMES Identity / Dereplication Taxonomic Characterization of Prokaryotic Microorganisms Screening Enzymes from Extreme Environments Cell-Based Screening Methods for Anti-Infective Compounds Metabolomics for the Discovery of Novel Compounds Methods to Access Silent Biosynthetic Pathways SECTION II FERMENTATION AND CELL CULTURE Miniaturization of Fermentations Solid-Phase Fermentation: Aerobic and Anaerobic Bacterial Cultivation for Production of Proteins and Other Biological Products Heterologous Protein Expression in Yeasts and Filamentous Fungi Mammalian Cell Culture for Biopharmaceutical Production Manufacture of Mammalian Cell Biopharmaceuticals Plant Cell Culture Insect Cell Culture SECTION III GENETICS, STRAIN IMPROVEMENT, AND RECOMBINANT PROTEINS Genetic Manipulation of Clostridium Genetic Engineering of Corynebacteria Genetic Manipulation of Myxobacteria Strain Improvement of Escherichia coli to Enhance Recombinant Protein Production Genetic Engineering Tools for Saccharomyces cerevisiae Protein Expression in Nonconventional Yeasts Genetics, Genetic Manipulation, and Approaches to Strain Improvement of Filamentous Fungi Genetic Manipulations of Mammalian Cells for Protein Expression SECTION IV GENETIC ENGINEERING OF SECONDARY METABOLITE SYNTHESIS Glycosylation of Secondary Metabolites to Produce Novel Compounds Metabolic Engineering of Escherichia coli for the Production of a Precursor to Artemisinin, an Antimalarial Drug Heterologous Production of Polyketides in Streptomyces coelicolor and Escherichia coli Genetic Engineering of Acidic Lipopeptide Antibiotics Genetic Engineering to Regulate Production of Secondary Metabolites in Streptomyces Genetic Engineering of Myxobacterial Natural Product Biosynthetic Genes SECTION V INDUSTRIAL ENZYMES, BIOCATALYSIS, AND ENZYME EVOLUTION Tools for Enzyme Discovery Enzyme Engineering: Combining Computational Approaches with Directed Evolution Enzyme Engineering by Directed Evolution Industrial Applications of Enzymes as Catalysts Biomass-Converting Enzymes and Their Bioenergy Applications The Use of Enzymes for Non-Aqueous Organic Transformations Enzyme Promiscuity and Evolution of New Protein Functions Enzyme Production in Escherichia coli Bioprocess Development SECTION VI MICROBIAL FUELS (BIOFUELS) AND FINE CHEMICALS Accessing Microbial Communities for Solutions to Biofuels Production Micro-Algal Culture as a Feedstock for Bioenergy, Chemicals, and Nutrition Metabolic Engineering Strategies for Production of Commodity and Fine Improving Microbial Robustness Using Systems Biology Bioethanol Production from Lignocellulosics: Some Process Considerations and Procedures Surface Microbiology of Cellulolytic Bacteria Physiological and Methodological Aspects of Cellulolytic Microbial Cultures SECTION VII BIOLOGICAL ENGINEERING AND SCALE-UP OF INDUSTRIAL PROCESSES Raw Materials Selection and Medium Development for Industrial Fermentation Processes Scale-Up of Microbial Fermentation Process Cell Culture Bioreactors: Controls, Measurements, and Scale-Down Model Continuous Culture Advances in Sensor and Sampling Technologies in Fermentation and Mammalian Cell Culture Bioreactor Automation Purification and Characterization of Proteins