Simulation for Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective

By:

Kimko, Hui C

Contributor(s):

Duffull, Stephen B

Material type: Text

TextSeries: Drugs and the Pharmaceutical Sciences ; Vol. 127Publication details: New York Marcel Dekker, Inc. 2003Description: 396pISBN:

9780824708627

Subject(s):

DDC classification:

615.7 KIM

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Holdings
Item type	Current library	Item location	Collection	Call number	Status	Date due	Barcode	Item holds
Reference Book	NIMA Knowledge Centre	6th Floor Silence Zone	Reference	615.7 KIM (Browse shelf(Opens below))	Not For Loan		P0004201
Book	NIMA Knowledge Centre	9th Floor Reading Zone	General	615.7 KIM (Browse shelf(Opens below))	Available		P00965

Total holds: 0

Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to clinical trial designs according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

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