Ophthalmic Drug Delivery Systems

Extensively revised and updated, this second edition compares conventional and innovative drug delivery systems. The book covers significant ophthalmic advances and breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery. It examines procedures in pharmacokinetic/pharmacodynamic modeling for the determination of appropriate dosing regimens, covers new developments in animal modeling, and discusses current regulations governing patenting, commercial product release, and human testing. This in-depth reference lays the groundwork for overcoming constraints on the delivery of ophthalmic drugs. fluorescein glucuronide, transcorneal iontophoresis, transscleral iontophoresis, injection displaced, compartmental shells, retinal permeability, ocular iontophoresis, pigmented rabbit conjunctiva, following topical ocular administration, ocular pharmacokinetics, intraocular entry, vitreous site, noncorneal route, conjunctival permeability, noncorneal penetration, rabbit conjunctival epithelial cells, aqueous humor volume, corneal drug penetration, following systemic drug administration, noncorneal pathway, ocular gene therapy, shields hydrated, collagen shields, collagen shield delivery, precorneal area