000 03766nam a2200265Ia 4500
008 140223b2006 xxu||||| |||| 00| 0 eng d
020 _a9780123694171
_c0.00
082 _a615.1
_bATK
100 _aAtkinson, Arthur J.
_915278
245 _aPrinciples of Clinical Pharmacology
250 _a2nd ed
260 _aAmsterdam
_bElsevier Academic Press
_c2006
300 _a545p
500 _aIntroduction to Clinical Pharmacology Pharmacokinetics Clinical Pharmacokinetics Compartmental Analysis of Drug Distribution Drug Absorption and Bioavailability Effects of Renal Disease on Pharmacokinetics This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. * Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy. * Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course. * Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study. * Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry. * Expanded coverage of pharmacogenetics * Expanded coverage of drug transporters and their role in interactions * Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions * A new chapter on drug discovery that focuses on oncologic agents * Inclusion of therapeutic antibodies in chapter on biotechnology products Pharmacokinetics in Patients Requiring Renal Replacement Therapy Effects of Liver Disease on Pharmacokinetics Noncompartmental Vs. Compartmental Approaches to Pharmacokinetic Analysis Distribution Models of Drug Kinetics Population Pharmacokinetics Drug Metabolism and Transport Pathways of Drug Metabolism Methods of Analysis of Drugs and Drug Metabolites Clinical Pharmacogenetics Drug Interactions Biochemical Mechanisms of Drug Toxicity Equilibrate and Concentrative Drug Transport Mechanisms Assessment of Drugs Effects Physiological and Laboratory Markers of Drugs Effect Dose Effect and Concentration - Effect Analysis Kinetic Analysis of Pharmacologic Effect Diseases Progress Models Optimizing and Evaluating Patient Therapy Pharmacological Differences Between Men and Women Drug Therapy in Pregnant and Nursing Women Drug Therapy in Neonates and Pediatric Patients Drug Therapy in the Elderly Clinical Analysis of Adverse Drug Reactions Quality Assessment of Drug Therapy Drug Discovery and Development
600 _aClinical Pharmacology
_915279
700 _aMarkey, Sanford P.
_915280
700 _aDaniels, Charles E.
_915281
700 _aDedrick, Robert L.
_915282
700 _aAbernethy, Derrell R.
_915283
942 _2ddc
_cLB
_k615.1
_mATK
995 _aPharmacy Lending
_eP0002661
_j615.1
_yP0002661
995 _aPharmacy Lending
_eP0002881
_j615.1
_yP0002881
995 _aPharmacy Lending
_eP0004610
_j615.1
_yP0004610
995 _aPharmacy Reference
_eP0002662
_j615.1
_yP0002662
999 _c14140
_d14140