000 | 01934nam a2200169Ia 4500 | ||
---|---|---|---|
008 | 140223b2007 xxu||||| |||| 00| 0 eng d | ||
020 |
_a9781405133586 _c0.00 |
||
082 |
_a615.1901 _bANA |
||
245 | _aAnalysis of Drug Impurities | ||
260 |
_aOxford _bBlackwell Publishers Ltd. _c2007 |
||
300 | _a275p | ||
500 | _aA key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods.Written for both practicing and student analytical chemists, Analysis of Drug Impurities provides a detailed overview of the challenges and the techniques available to permit accurate identification and quantification of drug impurities. active pharmaceutical ingredient, pharmaceutical analysis, stereochemical impurities, proton reference spectrum, drug impurities, stereoisomeric impurities, cryogenic flow probe, drug substance impurities, impurity identification, transient diastereomeric complexes, stereoisomeric purity, genetic toxins, product ion scan, exchangeable hydrogen atoms, cone voltage, new impurity, preparative isolation, product ion spectra, new drug substances, retest date, solvent suppression, chiral selectors, process impurities, active volume, toxic impurities | ||
700 |
_aSmith, Richard J. _eEditor _9108099 |
||
700 |
_aWebb, Michael L. _eEditor _9108100 |
||
942 |
_2ddc _cLB |
||
995 |
_aPharmacy Reference _eP0006908 _j615.1901 _yP0006908 |
||
999 |
_c15017 _d15017 |