000 01934nam a2200169Ia 4500
008 140223b2007 xxu||||| |||| 00| 0 eng d
020 _a9781405133586
_c0.00
082 _a615.1901
_bANA
245 _aAnalysis of Drug Impurities
260 _aOxford
_bBlackwell Publishers Ltd.
_c2007
300 _a275p
500 _aA key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods.Written for both practicing and student analytical chemists, Analysis of Drug Impurities provides a detailed overview of the challenges and the techniques available to permit accurate identification and quantification of drug impurities. active pharmaceutical ingredient, pharmaceutical analysis, stereochemical impurities, proton reference spectrum, drug impurities, stereoisomeric impurities, cryogenic flow probe, drug substance impurities, impurity identification, transient diastereomeric complexes, stereoisomeric purity, genetic toxins, product ion scan, exchangeable hydrogen atoms, cone voltage, new impurity, preparative isolation, product ion spectra, new drug substances, retest date, solvent suppression, chiral selectors, process impurities, active volume, toxic impurities
700 _aSmith, Richard J.
_eEditor
_9108099
700 _aWebb, Michael L.
_eEditor
_9108100
942 _2ddc
_cLB
995 _aPharmacy Reference
_eP0006908
_j615.1901
_yP0006908
999 _c15017
_d15017