000			02189nam a2200205Ia 4500
008			140223b2000 xxu||||| |||| 00| 0 eng d
020			_a9780824703943 _c0.00
082			_a573.8621 _bBLO
245			_aBlood - Brain Barrier and Drug Delivery to the CNS
260			_aNew York _bMarcel Dekker, Inc. _c2000
300			_a248p
500			_aThis timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS · assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans · presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters · examines the multidrug resistance protein P-glycoprotein as a natural transporter · analyzes current drug designs to known requirements for transport · looks at drug delivery systems for the brain · and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these
600			_aBlood _918400
600			_aDrug Delivery _918401
700			_aBegley, David J. _eEditor _918402
700			_aBradbury, Michael W. _eEditor _918403
700			_aKreuter, Jorg _eEditor _918404
942			_2ddc _cLB _k573.8621 _mBLO
995			_aPharmacy Reference _eP0005627 _j573.8621 _yP0005627
999			_c15119 _d15119