000			01916nam a2200169Ia 4500
008			140223b2007 xxu||||| |||| 00| 0 eng d
020			_a9780470049624 _c0.00
082			_a615.9001 _bCOM
245			_aComputational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals
260			_aNew Jersey _bJohn Wiley & Sons Inc. _c2007
300			_a814p
500			_aA comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals.This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:An introduction to toxicology methods and an explanation of computational methods,In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels, Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena, Chapters written by leading international experts, Figures that illustrate computational models and references for further information, This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.
600			_aToxicology _94977
700			_aEkins, Sean _eEditor _917127
942			_2ddc _cLB _k615.9001 _mCOM
995			_aPharmacy Reference _eP0005178 _j615.9001 _yP0005178
999			_c15299 _d15299