000			02338nam a2200169Ia 4500
008			140223b2006 xxu||||| |||| 00| 0 eng d
020			_a9780854048427 _c0.00
082			_a615.19 _bEXP
245			_aExploring Chemical Diversity for Drug Discovery
260			_aCambridge _bThe Royal Society of Chemistry _c2006
300			_a420p
500			_aAn excellent introduction to evolving methodologies' Carl Kaiser .Journal of Medicinal Chemistry .Conceptual and technological advances in chemistry and biology have transformed the drug discovery process. Evolutionary pressure among the diverse scientific and engineering disciplines that contribute to the identification of biologically active compounds has resulted in synergistic improvements at every step in the process. Exploiting Chemical Diversity for Drug Discovery encompasses the many components of this transformation and presents the current state-of-the-art of this critical endeavour. From the theoretical and operational considerations in generating a collection of compounds to screen, to the design and implementation of high-capacity and high-quality assays, this book provides a comprehensive overview of modern approaches to lead identification. Beginning with an introductory overview, subsequent chapters address topics that include the design of chemical libraries and methods for optimizing their diversity; automated and accelerated chemistry; high throughput assay design and detection techniques; and strategies for data analysis and property optimization. Written by experts in the field, both academic and industrial, and illustrated in full colour, this book provides an excellent overview for current practitioners and will also serve as a stimulating resource for future generations. Researchers in organic and medicinal chemistry, biological and pharmacological sciences, as well as those interested in allied computational and engineering disciplines, will value the comprehensive and up-to-date coverage. The book is an excellent and astonishinglycomplete compilation on this broad and demanding topic for current practicioners.'
700			_aBartlett, Paul A. _eEditor _9108439
700			_aEntzeroth, Michael _eEditor _9108440
942			_2ddc _cLB
995			_aPharmacy Reference _eP0006904 _j615.19 _yP0006904
999			_c15517 _d15517