000			01524ngm a2200145Ia 4500
008			140223b2010 xxu||||| |||| 00| 0 eng d
082			_a660.6 _bBHA
245			_aInhibition of Virulence Factors Controlled by Quorum Sensing in Pseudomonas Aeruginosa Using Plant Extrcts _cby Arpan, Bhatt, and Hasrajani, Vinita
260			_aAhmedabad _bInstitute of Science, Nirma University _c2010
300			_a79p
500			_aABSTRACT: Quorum sensing (QS), most commonly known as to be cell to cell signaling in bacteria, is a key regulator of virulence and biofilm formation in Pseudomonas aeruginosa and other medically relevant bacteria. In this study, five different plants of Indian origin were examined for their inhibitory effects against virulence caused by P.aeruginosa, which are under the control of Quorum sensing. The plant used are Terminalia belerica, Terminalia chebula, Vernonia anthelmintica, Nigella sativa and Moringa oleifera. Out of five plants used, T. bellerica, N. sativa and M. oleifera significantly reduced LasA and LasB activity. All five plants reduced the pyocyanin production. Additionally T. bellerica reduced the biofilm formation, which is partially regulated by QS. Plants reducing the virulence factor production marginally affect the growth of the organisms, so it suggests that anti-QS effect of plant extract is independent of any static or cidal effects.
700			_aBhatt, Arpan and Hasrajani, Vinita. _913738
942			_2ddc _cDIS
995			_aScience Dissertation _eSDR00083 _j660.6 _ySDR00083
999			_c20679 _d20679