Inhibition of Virulence Factors Controlled by Quorum Sensing in Pseudomonas Aeruginosa Using Plant Extrcts by Arpan, Bhatt, and Hasrajani, Vinita

ABSTRACT: Quorum sensing (QS), most commonly known as to be cell to cell signaling in bacteria, is a key regulator of virulence and biofilm formation in Pseudomonas aeruginosa and other medically relevant bacteria. In this study, five different plants of Indian origin were examined for their inhibitory effects against virulence caused by P.aeruginosa, which are under the control of Quorum sensing. The plant used are Terminalia belerica, Terminalia chebula, Vernonia anthelmintica, Nigella sativa and Moringa oleifera. Out of five plants used, T. bellerica, N. sativa and M. oleifera significantly reduced LasA and LasB activity. All five plants reduced the pyocyanin production. Additionally T. bellerica reduced the biofilm formation, which is partially regulated by QS. Plants reducing the virulence factor production marginally affect the growth of the organisms, so it suggests that anti-QS effect of plant extract is independent of any static or cidal effects.